Five years ago, the melting of arctic permafrost released an unknown pathogen into the atmosphere, causing a small percentage of people to undergo a transformation that made them intolerant to normal food, and only able to gain sustenance by consuming the flesh of other human beings. However, scientists were able to create a synthetic version of human meat that would satisfy these people's (dubbed ghouls) hunger. Zoey, Celeste, Valeria, and Jasmine are all ghouls living in Southern California. As a last hurrah before their graduation they decided to attend a musical festival in the desert. But on the first night of the festival Val goes feral, and ends up killing and eating a boy. As other festival guests start disappearing around them the girls soon discover someone is drugging ghouls and making them feral. And if they can't figure out how to stop it, and soon, no one at the festival is safe...