Life in the Area-51-like government facility, The Playroom, is safely tucked away from the prying eyes of the judgmental world, where Irregularities can learn to control their powers and restrain their monstrosity. But everything changes when a security breach at The Playroom thrusts Omar, Sylvie, Clarice, Jaali, Newt, and Maggie out into the real world, to fight for their lives against a group of fanatical conspiracy theorists called FREAKISH, and the threatening specter of The Collector who always seems to know where the crew is headed next. When the kids learns of the The Sanctuary, a place rumored to be a refuge for those like them, it may be their only option left. But their journey will take them through some dire straits that will test their mettle, and force them to examine what it is that makes each of them human.