In medicine, every patient presents with a story. “Once upon a time I was well, and then . . . ” These patient narratives are the beating heart of medicine; through stories we strive to communicate, to understand, to empathize, and perhaps find healing. These Vital Signs is a poignant series of essays—deeply personal stories—inspired by nephrologist Sayed Tabatabai’s medical experience and based on a series of poems he posted on Twitter that began going viral at the height of the Covid pandemic. Each short work is a poignant glimpse into the ever-changing field of medicine and the special relationship between patients and their doctor. In each, Tabatabai beautifully evokes the emotional tension between life and death, wellness and disease, uncertainty and hope, in a unique and unforgettable way.