As the COVID-19 pandemic revealed, we have become not just a hyper-partisan society but also a deeply cynical one, distrustful of traditional sources of knowledge and wisdom. Skepticism about vaccines led to the needless deaths of at least 230,000 Americans. Yet experts can make mistakes, and institutions can lose their moral compass. So how can we navigate through all this? Francis Collins reminds us of the four core sources of judgement and clear thinking: truth, science, faith, and trust. Collins makes a robust, thoughtful case for each of these sources—their reliability, and their limits. Ultimately, he shows how they work together, not separately—and certainly not in conflict. It is only when we relink these four foundations of wisdom that we can begin to discern the best path forward in life. This is a book that will repay many readings, and resolve dilemmas that we all face every day.