Every weekend, in Holland’s most popular newspaper, de Volkskrant, renowned science-journalist Ellen de Visser asks a different medical professional to tell her about ‘that one patient’; the patient who changed everything for them. Every day, in every country, thousands of patients share their stories with their doctors: stories they may never have told anyone else; stories that are heartbreaking, sometimes funny, and—just occasionally—unforgettable. To be able to do their job to the best of their abilities, medical experts use their ‘professional empathy’: they sympathize with their patients but try to keep themselves at a distance. But there is always that one patient who, for whatever reason, bridges this distance and often unwittingly, has a lasting impact on their doctor’s life. That One Patient is brimming with intimate stories of connection and of the unanticipated ways we can affect one other’s lives. All of them remind us of just how extraordinary humans can be, and of our incredible capacity for bravery, strength and humour.