Thirteen‑year‑old middle child Ruthy disappeared after track practice without a trace. Twelve years later, oldest sister Jessica spots a woman on her TV screen in Catfight, a raunchy reality show. She rushes to tell her younger sister, Nina: This woman's hair is dyed red, and she calls herself Ruby, but the beauty mark under her left eye is instantly recognizable. The years since Ruthy's disappearance haven't been easy on the Ramirez family. It’s 2008, and their mother, Dolores, still struggles with the loss, Jessica juggles a newborn baby with her hospital job, and Nina has returned home to medical school rejections and is forced to work in the mall folding tiny bedazzled thongs at the lingerie store. Jessica and Nina hatch a plan to drive to where the show is filmed in search of their long‑lost sister. When Dolores catches wind of their scheme, she insists on joining, along with her pot-stirring holy roller best friend, Irene.